Heterogeneity and phenotypic plasticity of glial cells in the mammalian enteric nervous system
نویسندگان
چکیده
منابع مشابه
GABA in the Mammalian Enteric Nervous System.
gamma-Aminobutyric acid (GABA) is a transmitter of enteric interneurons, targeting excitatory GABA(A) or inhibitory GABA(B) receptors that modulate motility and mucosal function. Enteric GABA may also subserve hormonal and paracrine signaling. Disruption in gastrointestinal function following perturbation of enteric GABA receptors presents potential new target sites for drug development.
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Phenotypic expression in the developing murine enteric nervous system.
The development of the enteric nervous system was examined in fetal mice. Synthesis of [3H] acetylcholine ([3H]ACh) from [3H]choline and acetylcholinesterase histochemistry were used as phenotypic markers for cholinergic neurons, while the radioautographic detection of the specific uptake of [3H]serotonin (5-[3H]HT) and immunocytochemical staining with antiserum to 5-HT marked serotonergic neur...
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The enteric nervous system (ENS) in mammals forms from neural crest cells during embryogenesis and early postnatal life. Nevertheless, multipotent progenitors of the ENS can be identified in the adult intestine using clonal cultures and in vivo transplantation assays. The identity of these neurogenic precursors in the adult gut and their relationship to the embryonic progenitors of the ENS are ...
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Previous studies have demonstrated that when tritiated proline [( 3H]Pro) is injected into the dorsal column nuclei (DCN) of cats, it labels macroglial cells, but fails to label neurons at the injection site. (Tritiated leucine [( 3H]Leu) in contrast, labels both neurons and some glial cells.) Despite the failure of [3H]Pro to label DCN neurons, labeling is still observed in DCN terminal target...
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ژورنال
عنوان ژورنال: Glia
سال: 2014
ISSN: 0894-1491,1098-1136
DOI: 10.1002/glia.22746